Table 2.
List of genes containing significantly associated (P ≤ 0.05) SNPs replicated in multiple independent GWAS studies, and the P-values estimated using gene expression data derived from the Caucasian (EU), Asian and ER+ and ER− EU population.
| Gene name (symbol) | SNP ID (rs-ID*, replicated) | Range of SNP (P-value) | EU (P-value) | Asian (P-value) | ER+/ER−(P-value) |
|---|---|---|---|---|---|
| CASP8 | rs1045485** | 0.02–1.1 × 10−7 | 0.005 | 0.1 | 0.1 |
| ESR1 | rs3020314** | 8 × 10−5–8 × 10−5 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3020390** | 0.04–0.05 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3020394** | 0.003–0.003 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs1884051** | 0.03–0.03 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs2228480** | 0.002–0.006 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3020396** | 0.003–0.004 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3020400** | 0.005–0.005 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3020401** | 0.004–0.004 | 0.7 | 0.0006 | 5.00E-06 |
| ESR1 | rs3798577** | 0.04–0.004 | 0.7 | 0.0006 | 5.00E-06 |
| FGFR2 | rs2981582******* | 0.01–2 × 10−76 | 5.00E-06 | 0.1 | 0.4 |
| FGFR2 | rs2981579***** | 0.02–1.79 × 10−31 | 5.00E-06 | 0.1 | 0.4 |
| FGFR2 | rs2420946****** | 0.03–3.5 × 10−6 | 5.00E-06 | 0.1 | 0.4 |
| FGFR2 | rs1219648****** | 0.01–3.2 × 10−6 | 5.00E-06 | 0.1 | 0.4 |
| LSP1 | rs3817198**** | 6.51 × 10−2–3.0 × 10−9 | 0.6 | 0.1 | 0.01 |
| STXBP4 | rs6504950** | 0.04–1.4 × 10−8 | 0.7 | – | – |
| TGFB1 | rs1800470*** | 0.01–2.8 × 10−5 | 0.0007 | 0.8 | 0.5 |
| TOX3 | rs12443621** | 1 × 10−12–2 × 10−19 | 0.0001 | 6.50E-05 | 7.00E-05 |
| ADH1B | rs1042026*** | 0.02–0.03 | 5.00E-06 | 5.0E-06 | 0.04 |
| SORBS1 | rs10450393** | 0.01–0.02 | 0.4 | 0.01 | 0.63 |
| ICAM5 | rs1056538** | 0.05–001 | 0.9 | 0.01 | 0.49 |
| RB1 | rs198580** | 0.02–0.02 | 0.4 | 0.01 | 0.0001 |
| RNF146 | rs2180341** | 0.008–2.9 × 10−8 | 0.7 | – | 0.69 |
| RB1 | rs2854344** | 0.007–0.007 | 0.4 | 0.01 | 0.0001 |
| IGFBP3 | rs2854744**** | 0.06–0.03 | 0.0005 | 0.002 | 0.03 |
| CDKN1A | rs3176336** | 0.003–0.003 | 0.3 | 0.04 | 0.2 |
| CDKN1B | rs34330** | 0.01–0.01 | 0.9 | 0.7 | 5.00E-06 |
| CDKN2A | rs3731239** | 0.01–0.01 | 0.003 | 0.40 | 0.0001 |
| LOC643714 | rs3803662****** | 0.01–1 × 10−36 | 0.00E-05 | – | – |
| EHMT1 | rs4634736** | 0.02–1–0.02 | 7.50E-05 | 0.1 | 0.03 |
| SOD2 | rs4880** | 0.01–0.05 | 0.03 | 0.1 | 0.0008 |
| CCND1 | rs678653** | 0.05–0.002 | 0.81 | 0.3 | 5.00E-06 |
| HCN1 | rs981782** | 10−5–10−2 | 0.008 | – | – |
| CCNE1 | rs997669** | 0.003–0.003 | 5.00E-06 | 0.07 | 5.00E-06 |
| RAD51L1 | rs999737** | 1.74 × 10−7 | 0.5 | 0.1 | 8.00E-05 |
Note:
*
Indicates the number of times the SNP has been replicated in multiple independent studies.