Table 1.
Mean urinalysis data from male and female hybrid rats at 5 and 8 month stages during maintenance on OTA-contaminated feed (5 ppm), and correspondingly from female controls. Creatinine values are mmol/L. Other solute parameters are expressed as µmol/mmol creatinine, particularly to accommodate the marked polyuria in OTA-treated females.
| Months on OTA or as controls | Rats (n) | Urine vol (mL) | Creatinine | Ca | Urate | Protein | Na | K | Phosphate | Urea | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | 5 | 4 | 7.98 | 12.04 | 0.24 | 0.16 | 0.20 | 11.87 | 23.67 | 0.24 | 90.55 |
| (OTA) | 8 A | 4 | 11.37 | 9.18 | 0.30 | 0.12 | 0.19 | 18.31 | 24.09 | 0.89 | 91.45 |
| 8 B | 7 | 8.36 | 11.27 | 0.34 | 0.11 | 0.20 | 11.73 | 18.91 | 0.09 | 69.99 | |
| Female | 5 | 3 | 14.67 | 3.69 | 1.38 | 0.23 | 0.06 | 17.80 | 36.54 | 2.24 | 119.9 |
| (OTA) | 8 A | 3 | 20.67 | 3.74 | 1.30 | 0.23 | 0.08 | 26.40 | 35.08 | 1.97 | 123.2 |
| 8 B | 3 | 13.4 | 2.81 | 1.22 | 0.24 | 0.07 | 19.56 | 35.06 | 0.82 | 122.7 | |
| Female | 5 | 3 | 9.20 | 6.63 | 1.12 | 0.15 | 0.04 | 12.72 | 24.96 | 2.27 | 93.80 |
| (control) | 8 | 3 | 10.83 | 5.08 | 1.38 | 0.16 | 0.04 | 16.87 | 24.89 | 1.52 | 105.6 |