Table 2.

Ongoing clinical trials testing dietary phytochemicals ¹.

Trial Lead Organizations	Therapy		Phase		Type of cancer
	Polyphenol	Other treatments
University of Texas - M.D. Anderson Cancer Center	Phenethyl isothiocyanate	Fludarabine	I	Active	Lymphoproliferative disorders
Mayo Clinic Cancer Center	17-AAG 2	Gemcitabine	II	Active	Recurrent Advanced Ovarian Epithelial or Primary Peritoneal Cavity Cancer
Mayo Clinic Cancer Center	17-AAG 2	Bortezomib	I	Active	Advanced solid tumors and lymphomas
Oregon Health and Science University - Knight Cancer Institute	Broccoli sprout extract		II	Active	Ductal carcinoma in situ and/or atypical ductal hyperplasia
University of Texas - M. D. Anderson Cancer Center	Curcumin		II	Active	Advanced pancreatic cancer
Rambam Medical Center	Curcumin	Gemcitabine	II	Active	Pancreatic cancer
Tel-Aviv Sourasky Medical Center	Curcumin	Gemcitabine and celecoxib	III	Active	Advance or inoperable pancreatic cancer
University of Texas - M. D. Anderson Cancer Center	Curcumin	Radiotherapy and capecitabine	II	Active	Rectal cancer
Tata Memorial Hospital	Curcumin	Ashwagandha extract3	I/II	Active	Advanced osteosarcoma
Cleveland Clinic Taussig Cancer Center	Curcumin	Boswellia serrata4	II	Active	Newly diagnosed or recurrent high-grade gliomas
University of Texas - M. D. Anderson Cancer Center	Curcumin	Bioperine		Completed	Multiple Myeloma
Johns Hopkins University	Curcumin		II	Terminated	FAP5
Memorial Sloan-Kettering Cancer Center	Green Tea Extract		I	Completed	Advanced solid tumors
Louisiana State University Health Sciences - Feist-Weiller Cancer Center	Green Tea Extract		II	Active	Breast cancer progression
UCLA - Jonsson Comprehensive Cancer Center	Green Tea - Black tea		II	Active	Prostate adenocarcinoma
University of Texas - M. D. Anderson Cancer Center	Polyphenon E 6		I	Closed	Breast cancer
University of Wisconsin - Paul P. Carbone Comprehensive Cancer Center	Polyphenon E 6		II	Active	Bladder Cancer
Barbara Ann Karmanos Cancer Institute	Polyphenon E 6		II	Active	MGUS7 and Multiple Myeloma
Mayo Clinic Cancer Center	Polyphenon E 6		II	Active	Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Louisiana State University Medical Center - Stanley S. Scott Cancer Center	Polyphenon E 6	Erlotinib8	I/II	Active	NSLC 9
Aker Universitetssykehus HF	Syntetic Genistein (Bonistein)		II	Closed	Prostate cancer
Northwestern University - Robert H. Lurie Comprehensive Cancer Center	Genistein		II	Closed	Prostate cancer
Barbara Ann Karmanos Cancer Institute	Genistein	Gemcitabine	II	Completed	Breast cancer
University of North Carolina - Chapel Hill - Lineberger Comprehensive Cancer Center	Genistein		I	Closed	Prostate Cancer
Robert H. Lurie Comprehensive Cancer Center at Northwestern University	Genistein	Interleukin-2	II	Closed	Metastatic Melanoma or kidney cancer
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center	Genistein		II	Closed	Bladder cancer
Barbara Ann Karmanos Cancer Institute	Genistein	Gemcitabine, and Erlotinib	II	Closed	Pancreatic Cancer
University of Minnesota - Masonic Cancer Center	Genistein		I/II	Active	Osseous Metastases
Parker Hughes Cancer Center	Genistein immunoconjugate		I	Closed	Recurrent B-cell Acute Lymphoblastic Leukemia or NHL 10
Barbara Ann Karmanos Cancer Institute	Soy isoflavones		II	Closed	Adenocarcinoma of the Prostate
H. Lee Moffitt Cancer Center CCOP Research Bas	Soy isoflavones		NS	Closed	Breast cancer
Barbara Ann Karmanos Cancer Institute	Soy isoflavones	Radiotherapy	II	Closed	Prostate cancer
Wake Forest University Comprehensive Cancer Center	Soy isoflavones	Cholecalciferol	II	Active	Prostate cancer
University of South Florida - H. Lee Moffitt Cancer Center and Research Institute	Purified isoflavones		II	Active	Prostate Cancer
Novogen, Incorporated	Phenoxodiol 11		I	Completed	Refractory solid tumors
Yale Cancer Center	Phenoxodiol 11	Docetaxel	I/II	Active	Ovarian epithelial, fallopian tube or primary peritoneal cavity cancer
Marshall Edwards, Inc.	Phenoxodiol 11		II	Active	Prostate cancer
University of Texas - M. D. Anderson Cancer Center	Lycopene		II	Closed	Prostate cancer
H. Lee Moffitt Cancer Center and Research Institute	Lycopene			Completed	Prostate cancer
University of Illinois Cancer Center	Lycopene		NS	Closed	Prostate cancer or benign prostatic hyperplasia
North Central Cancer Treatment Group	Lycopene		II	Completed	Metastatic prostate cancer
USC/Norris Comprehensive Cancer Center and Hospital	Lycopene	Supplements12	II	Active	Recurrent prostate cancer
Toronto Western Hospital	Lycopene	Antioxidants13	II	Active	Early stage prostate cancer
Toronto Western Hospital	Lycopene	Antioxidants13	II	Active	Prostate cancer
Ohio State University Medical Center - Arthur G. James Cancer Hospital and Solove Research Institute	Tomato-Soy Juice		I/II	Active	Prostate cancer
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center	Resveratrol		I/II	Closed	Colon Cancer
University of Michigan - Comprehensive Cancer Center	Resveratrol		I	Active	Resectable colorectal cancer
GlaxoSmithkline	SRT50114		I	Active	Colorectal cancer and hepatic metastases
GlaxoSmithkline	SRT50114	Bortezomib	II	Active	Multiple Myeloma

¹ Deducted primarily from http://www.cancer.gov/clinicaltrials; ² 17-N-allylamino-17-demethoxygeldanamycin; ³ Ingredients from traditional Indian medicine with potent anti-cancer compounds in laboratory as well as animal studies; ⁴ Extracts of Boswellia serrata are used in traditional herbal medicine in India and in African countries. Animal experiments show anti-inflammatory activity of the extract; ⁵ Familial Adenomatous Polyposis; ⁶ A decaffeinated green tea catechin mixture containing about 50% EGCG and 30% other catechins; ⁷ Monoclonal Gammopathy of Undetermined Significance; ⁸ EFGR tyrosine kinase inhibitor; ⁹ Non-Small Cell Lung Cancer; ¹⁰ Non-Hodgkin's Lymphoma; ¹¹ Synthetic genistein; ¹² contains vitamin D3, vitamin E, selenium, green tea extract, saw palmetto, lycopene, and soy derivatives; ¹³ vitamin E, selenium and lycopene; ¹⁴ SRT501 is a proprietary chemical developed by Sirtris based on the naturally occurring resveratrol; NS, not specified.