Table 2.
Comparative uro-analytical findings from groups of rats surviving at ~2 years of age. They had been consuming ochratoxin A-contaminated diet for 35 weeks from 50 weeks of age. At 85 weeks of age, one group remained on the OTA diet while the other reverted to normal rat diet. Ultimate principal oncological findings are given for each animal. Kidney indicates the individuals in which renal adenoma was later found. Units; urine (18 h, mL), creatinine (mmol/L), protein (g/L), other solutes (mmol/mmol creatinine).
| Prospective oncology | Volume | Calcium | Urate | Creatinine | Protein | Sodium | Potassium | Phosphate | Urea |
|---|---|---|---|---|---|---|---|---|---|
| Continuous OTA | |||||||||
| Testis | 7.6 | 0.24 | 0.30 | 9.75 | 0.72 | 3.6 | 17.53 | 4.08 | 76.18 |
| Testis * | 11.7 | 0.53 | 0.23 | 6.14 | 1.84 | 9.15 | 22.65 | 3.32 | 77.22 |
| Testis * | 8.0 | 0.12 | 0.25 | 8.35 | 1.11 | 6.08 | 16.17 | 4.21 | 68.14 |
| Kidney | 8.1 | 0.16 | 0.20 | 10.77 | 0.64 | 6.13 | 15.69 | 3.14 | 67.49 |
| Testis, Leukemia | 12.0 | 0.36 | 0.45 | 5.81 | 2.25 | 6.80 | 16.88 | 6.12 | 64.41 |
| Mean | 9.5 | 0.28 | 0.29 | 7.56 | 1.31 | 6.35 | 17.78 | 4.17 | 70.69 |
| OTA ceased for 22 weeks | |||||||||
| Kidney (unilateral, total; 6.4 g) | 12.4 | 0.11 | 0.28 | 7.84 | 0.62 | 5.33 | 14.54 | 3.35 | 56.12 |
| Testis, Leukemia, Kidney | 12.0 | 0.25 | 0.39 | 7.73 | 0.35 | 6.53 | 15.39 | 2.80 | 61.80 |
| Testis, subcutaneous sarcoma | 13.0 | 0.46 | 0.28 | 5.41 | 0.88 | 8.17 | 19.77 | 4.17 | 76.11 |
| Leukemia, Kidney * | 10.7 | 0.57 | 0.27 | 8.20 | 0.87 | 6.14 | 16.47 | 3.33 | 59.54 |
| Mean | 12.0 | 0.35 | 0.31 | 7.30 | 0.68 | 6.54 | 16.54 | 3.41 | 63.39 |
* Histology of perfusion-fixed brain studied.