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DON-induced ribotoxic stress—Mechanism I. One mechanism for DON-induced ribotoxic stress is proposed to involve: (1) rapid DON uptake and binding to ribosome; (2) activation of ribosomal-associated PKR and Hck; (3) interaction of p38 with the ribosome; (4) p38 phosphorylation and (5) induction of proinflammatory genes.
