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. 2009 Oct 12;25(4):769–781. doi: 10.1359/jbmr.091017

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Copyright © 2010 American Society for Bone and Mineral Research

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Fig. 3 — ERα^NERKI^/− mice have low bone mass and lose cancellous bone following OVX. (A) Femoral and spinal BMD determined in 5-month-old mice of the indicated genotypes using Piximus (n = 26 to 31 per group). The box indicates the interquartile range around the median (white square inside the box), and the vertical lines represent values plus or minus 1.5 times the interquartile range. (B) Vertebral dimensions and femoral bone area were determined in mice described in A using a micrometer and Piximus, respectively (n = 7 to 11 per group). (C) Representative photomicrographs of lumbar vertebrae from three mice per genotype, unstained and viewed at 25× without coverslips. (D) Vertebral cancellous bone volume (BV/TV) and (E) cortical thickness of tibiae as determined by µCT in ERα^+/+ or ERα^NERKI^/− mice from the experiment described in 1C (n = 7 to 11 per group). *p < .05 versus +/+; ^†p < .05 versus OVX.