Table 1.
µCT Measurements of Lumbar Cancellous Bone (L5) and Mid-Diaphyseal Tibial Cortical Bone in ERα+/+, ERα+/−, ERαNERKI/+, and ERαNERKI/− Female Mice
| µCT Measurements | ERα+/+ | ERα+/− | ERαNERKI/+ | ERαNERKI/− |
|---|---|---|---|---|
| 3D-BMD (mg HA/cm3) | 298.9 ± 24.7 | 238.0 ± 48.4 | 271.1 ± 61.3 | 200.5 ± 48.7* |
| BV/TV % | 39.5 ± 3.8 | 32.3 ± 6.2 | 37.7 ± 9.4 | 28.0 ± 6.6* |
| Trabecular number (per mm) | 4.98 ± 0.32 | 4.56 ± 0.57 | 5.31 ± 0.96 | 4.79 ± 0.56 |
| Trabecular thickness (µm) | 70.7 ± 2.7 | 65.5 ± 5.7 | 64.5 ± 5.8 | 56.9 ± 5.5* |
| Trabecular separation (µm) | 209.8 ± 16.8 | 224.3 ± 32.6 | 200.5 ± 34.4 | 209.6 ± 27.9 |
| Cortical thickness (mm) | 0.22 ± 0.011 | 0.21 ± 0.012 | 0.21 ± 0.016 | 0.19 ± 0.012* |
*
p < .05 versus ERα+/+ controls, n = 7–11.