Table 4.
Relationship of AED Use With Total Fractures by Number and Type of AED Used
| Events | Annual % | Model 1 HR (95% CI)a | Model 2 HR (95% CI)b | |
|---|---|---|---|---|
| Nonuser | 22,137 | 2.10 | 1.00 | 1.00 |
| Single AED user | 293 | 3.18 | 1.60 (1.42–1.79) | 1.37 (1.22–1.54) |
| Multiple AED user | 51 | 4.75 | 2.68 (2.04–3.53) | 2.12 (1.61–2.80) |
| Non-enzyme AED user | 138 | 2.86 | 1.44 (1.22–1.71) | 1.20 (1.02–1.42) |
| Enzyme AED user | 190 | 3.69 | 1.87 (1.62–2.15) | 1.64 (1.42–1.89) |
| Both AED type user | 16 | 5.39 | 3.02 (1.85–4.93) | 2.10 (1.28–3.43) |
a
Model 1 adjusted for age, ethnicity, BMI, and WHI trial participation and intervention.
b
Model 2 adjusted for age, race/ethnicity, BMI, smoking, alcohol, calcium and vitamin D intake, prevalent fractures (fracture at age 55+), prevalent falls (two or more in the year prior to enrollment), bisphosphonates, past/current use of HT, SERMs, calcitonin, age of menopause, physical activity levels, physical function construct, diabetes, stroke, parental history of hip fractures, study site region, self-reported health, MS, Parkinson's, and WHI trial participation and intervention.