Table 5.
Mean Bone Mineral Density (BMD, g/cm2 ± SE) and % Changes ± SE in Mean BMD by Current AED Use
| Antiepileptic user | Nonuser | |||||
|---|---|---|---|---|---|---|
| n | Meana (SE) | n | Mean* (SE) | p Valuea | p Valueb (adjusted) | |
| Initial measurement | ||||||
| Total hip | 83 | 0.84 (0.017) | 8644 | 0.87 (0.007) | .096 | .224 |
| Total spine | 82 | 0.96 (0.020) | 8392 | 0.98 (0.008) | .276 | .647 |
| Total body | 83 | 1.01 (0.013) | 8645 | 1.02 (0.005) | .304 | .777 |
| Final measurement | ||||||
| Total hip | 60 | 0.86 (0.020) | 7222 | 0.89 (0.008) | .127 | .289 |
| Total spine (final) | 60 | 0.98 (0.025) | 7017 | 1.01 (0.010) | .097 | .308 |
| Total body (final) | 60 | 1.01 (0.016) | 7190 | 1.04 (0.006) | .095 | .229 |
| 3-Year BMD change | ||||||
| % Change in total hip | 58 | 0.52 (0.576) | 7141 | 1.24 (0.220) | .180 | .312 |
| % Change in total spine | 58 | 4.15 (0.730) | 6962 | 2.91 (0.283) | .067 | .064 |
| % Change in total body | 57 | 1.34 (0.535) | 7119 | 1.42 (0.203) | .870 | .539 |
a
Adjusted for WHI trial participation and intervention.
b
Adjusted for age, race, BMI, smoking, alcohol, calcium and vitamin D intake, history of fractures (fracture at age 55+), history of falls (two or more in year prior to enrollment), bisphosphonates, past/current use of HT, SERMs, calcitonin, age of menopause, physical activity levels, physical function construct, diabetes, stroke, parental history of hip fractures, study site region, self-reported health, multiple sclerosis, Parkinson's, WHI trial participation, and intervention.