Table 3.
Multivariable Models in Which Age, BMI, and Serum Serotonin Levels Were Used as Predictors
| Outcome | Group | Predictors | β ± SEM | P value | Model R2 |
|---|---|---|---|---|---|
| Femur neck | |||||
| Total vBMD (mg/cm3) | All women | Age | −2.82 ± 0.20 | <.001 | 0.43 |
| BMI | 1.44 ± 0.65 | .028 | |||
| Serotonin | −0.16 ± 0.07 | .024 | |||
| Trabecular vBMD (mg/cm3) | All women | Age | −2.51 ± 0.14 | <.001 | 0.56 |
| BMI | 1.97 ± 0.46 | <.001 | |||
| Serotonin | −0.17 ± 0.05 | <.001 | |||
| Trabecular vBMD (mg/cm3) | Premenopausal women | Age | −2.88 ± 0.45 | <.001 | 0.36 |
| BMI | 1.74 ± 0.73 | .020 | |||
| Serotonin | −0.16 ± 0.07 | .029 | |||
| HRpQCT parametersa | |||||
| TbTh (mm) | All women | Age | −0.14 ± 0.04 | <.001 | 0.05 |
| Serotonin | −0.03 ± 0.01 | .028 | |||
| TbTh (mm) | Postmenopausal women not on HT | Serotonin | −0.06 ± 0.02 | .007 | 0.06 |
| BV/TV | Postmenopausal women not on HT | BMI | 2.04 ± 0.60 | .001 | 0.16 |
| serotonin | −0.14 ± 0.06 | .038 |
Note: Shown are the specific skeletal parameters and groups of women where serum serotonin levels were independent predictors in the models. vBMD = volumetric bone mineral density; TbTh = trabecular thickness; BV/TV = bone volume/total volume.
a
β and SEM are ×1000.