Table 6.
Trabecular (Tb) Bone Morphology and Density at the Proximal Tibial Metaphysis and Cortical (Ct) Bone Volume at the Mid-diaphysis Determined by µCT Before and After 5 Days of Tibial Loading—Osteoclast Surface Determined by Histology After Loading (Mean ± SD)
| 7 Months | 22 Months | |||||||
|---|---|---|---|---|---|---|---|---|
| Control (left) | Loaded (right) | Control (left) | Loaded (right) | |||||
| Outcome | Before (n = 12) | After (n = 12) | Before (n = 12) | After (n = 12) | Before (n = 12) | After (n = 7) | Before (n = 12) | After (n = 7) |
| Tb.BV/TV (mm3/mm3) | 0.181 ± 0.20 | 0.178 ± 0.04 | 0.157a ± 0.031 | 0.132a,b ± 0.031 | 0.098 ± 0.031 | 0.075b ± 0.017 | 0.085 ± 0.025 | 0.083 ± 0.046 |
| Tb.N (1/mm) | 4.4 ± 0.2 | 4.5 ± 0.3 | 4.5 ± 0.3 | 4.3 ± 0.3 | 3.9 ± 0.2 | 3.9 ± 0.2 | 3.8 ± 0.3 | 3.7 ± 0.3 |
| Tb.Th (mm) | 0.078 ± 0.004 | 0.077 ± 0.007 | 0.074a ± 0.004 | 0.070a ± 0.006 | 0.066 ± 0.008 | 0.060b ± 0.005 | 0.064 ± 0.008 | 0.059 ± 0.005 |
| Tb.vBMD (mg HA/cm3) | 180 ± 15 | 175 ± 21 | 160a ± 19 | 148a ± 19 | 119 ± 24 | 109b ± 15 | 108 ± 19 | 105 ± 29 |
| Tb.Oc.S/BS (%) | — | 2.8 ± 2.1 | — | 3.4 ± 2.4 | — | 3.0 ± 3.4 | — | 2.1 ± 1.0 |
| Cort.BV (mm3) | 0.378 ± 0.021 | 0.378 ± 0.025 | 0.385 ± 0.019 | 0.421a,b ± 0.039 | 0.360 ± 0.029 | 0.345b ± 0.027 | 0.359 ± 0.018 | 0.359 ± 0.017 |
a
Loaded (right) different from control (nonloaded, left) at same time point.
b
After different from before; p < .05, paired t test.