Table 1.
Cohorts Characteristics
| ICH Location | Lobar ICH | Lobar ICH | Lobar ICH | Deep ICH | Deep ICH | Deep ICH |
|---|---|---|---|---|---|---|
| Cohort | Discovery | Replication I | Replication II | Discovery | Replication I | Replication II |
| Ethnicity | European | European | African-American ancestry | European | European | African-American ancestry |
| No. of Subjects | 409 | 351 | 89 | 456 | 595 | 125 |
| Age in Years (Mean, SD) | 75·4 (10·6) | 73·5 (16·4) | 63·6 (17·3) | 69·9 (13·4) | 66·2 (14·3) | 60·1 (12·8) |
| Sex (n,% Female) | 172(42) | 172 (49) | 44 (49) | 178 (39) | 286(48) | 58 (46) |
| History of Hypertension (n,%) | 282 (69) | 193 (55) | 52 (58) | 383 (84) | 375(63) | 77 (62) |
| Warfarin Use (n,%) | 86 (21) | 67 (19) | 12(13) | 91(20) | 101(17) | 19 (15) |
| Aspirin Use (n,%) | 164 (40) | 112 (32) | 26 (29) | 178 (39) | 208 (35) | 37 (30) |
| ICH Volume in cc (Median, IQR) | 28·5 (10·5 – 49·0) | 26·3 (11·2 – 44·8) | 26·0 (10·1 – 53·2) | 12·6 (1·9 – 28·5) | 14·5 (3·2 – 39·0) | 18·8 (4·0 – 39·3) |
| Mortality (n,% 90 days) | 147 (36) | 116 (33) | 30 (34) | 164 (36) | 202 (34) | 47 (38) |
| Poor Outcome (n,% mRS 3–6 at 90 days) | 360 (88) | 309 (88) | 77 (87) | 140 (90) | 530 (89) | 115 (92) |
| APOE ε2 (MAF) | 0.11 | 0.12 | 0.15 | 0.08 | 0.09 | 0.11 |
| APOE ε4 (MAF) | 0.20 | 0.21 | 0.23 | 0.16 | 0.14 | 0.20 |
Discovery phase includes European ancestry subjects enrolled in the GOCHA study. Replication I includes European ancestry subjects enrolled in DECIPHER, GERFHS, HM-ICH, JUHSS, LUSR, and MUG-ICH. Replication II includes African-American subjects enrolled in DECIPHER, GERFHS and GOCHA.
GERFHS = Genetic and Environmental Risk Factors for Hemorrhagic Stroke (University of Cincinnati, Cincinnati, OH), GOCHA = Genetics Of Cerebral Hemorrhage on Anticoagulation, HM-ICH = Hospital del Mar (Barcelona, Spain) ICH study, ICH = Intracerebral hemorrhage, IQR = Interquartile Range, JUHSS = Jagiellonian University (Krakow, Poland) Hemorrhagic Stroke Study, LSR = Lund (Lund, Sweden) Stroke Registry (LSR), MAF = Minor Allele Frequency, mRS: modified Rankin Scale, MUG-ICH = Medical University of Graz (Graz, Austria) ICH study, SD = Standard Deviation