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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Lancet Neurol. 2011 Jul 6;10(8):702–709. doi: 10.1016/S1474-4422(11)70148-X

Table 2.

Univariate and Multivariate Analyses of ICH Volume in Discovery Samples

LOBAR ICH (n = 409)
Univariate Multivariate
Variable Coeff (SE) p-value Variable Coeff (SE) p-value
Age 0·024 (0·024) 0·33 Age 0·024 (0·022) 0·29
Sex −0·267 (0·149) 0·073 Sex −0·049 (0·045) 0·28
HTN 0·047 (0·160) 0·77 HTN 0·670 (0·731) 0·36
Warfarin Use 0·040 (0·184) 0·83 Warfarin Use 0·512 (1·379) 0·71
Aspirin Use −0·172 (0·154) 0·26 Aspirin Use −0·178 (0·719) 0·80
APOE ε2 0·471 (0·103) 1.4 × 10−5 APOE ε2 0·455 (0·108) 2·5 × 10−5
APOE ε4 0·083 (0·134) 0·54 APOE ε4 0·205 (0·131) 0·12
DEEP ICH (n = 456)
Univariate Multivariate
Variable Coeff (SE) p-value Variable Coeff (SE) p-value
Age 0·005 (0·005) 0·92 Age 0·005 (0·006) 0·93
Sex −0·11 (0·15) 0·45 Sex −0·11 (0·16) 0·47
HTN −0·12 (0·20) 0·54 HTN −0·15 (0·20) 0·46
Warfarin Use 0·071 (0·18) 0·71 Warfarin Use 0·08 (0·19) 0·67
Aspirin Use 0·072 (0·15) 0·64 Aspirin Use 0·085 (0·15) 0·58
APOE ε2 0·144 (0·186) 0·44 APOE ε2 0·130 (0·181) 0·48
APOE ε4 0·065 (0·140) 0·81 APOE ε4 0·070 (0·135) 0·62

Both univariate and multivariate analysis are adjusted for Principal Components 1 and 2 to eliminate possible confounding due to population stratification.

Coeff = Regression Cefficient, HTN = History of Hypertension, SE = Standard Error