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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Lancet Neurol. 2011 Jul 6;10(8):702–709. doi: 10.1016/S1474-4422(11)70148-X

Table 3.

APOE ε2 and ε4 and ICH volume

Phenotype Allele Discovery Replication I Replication II All subjects
Coeff. (SD) p Coeff. (SD) p Coeff. (SD) p Coeff. (SD) p
Lobar ICH Volume APOE ε2 0·455 (0·108) 2·5 × 10−5 0·418 (0·158) 8·0 × 10−3 0·397 (0·165) 0·016 0·434* (0·08) 3·2 × 10−8
APOE ε4 0·205 (0·131) 0·12 0·130 (0·250) 0·60 0·155 (0·323) 0·63 0·151 (0·109) 0·17
Deep ICH Volume APOE ε2 0·130 (0·181) 0·48 0·246 (0·415) 0·55 0·164 (0·409) 0·69 0·151 (0·154) 0·33
APOE ε4 0·070 (0·135) 0·62 −0·040 (0·235) 0·86 0·273 (0·308) 0·38 0·072 (0·110) 0·51
*

Corresponds to an average increase of 5.3 cc (95% Confidence Interval (CI): 4.7 – 5.9 cc), or approximately 18% of average lobar hematoma size at presentation, for each copy of the APOE ε2 allele.

Coeff. = Regression Coefficient, ICH = Intracerebral Hemorrhage, SD = Standard Deviation