Table 5.

APOE ε2 and ε4 and 90-day mortality and poor functional outcome

Phenotype	Allele	Discovery		Replication I		Replication II		All subjects
		OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Lobar ICH Mortality	APOE ε2	1·60 (1·13 – 2·25)	0·008	1·52 (1·06 – 2·17)	0·011	1·40 (1·01 – 1·93)	0·043	1·50 (1·23 – 1·82)	2·45 × 10−5
	APOE ε4	1·18 (0·85 – 1·64)	0·10	1·25 (0·74 – 2·12)	0·15	1·01 (0·73– 1·39)	0·95	1·12 (0·90 – 1·38)	0·31
Deep ICH Mortality	APOE ε2	0·68 (0·29 – 1·57)	0·36	1·11 (0·74 – 1·66)	0·78	0·90 (0·50 – 1·61)	0·72	0·98 (0·72 – 1·34)	0·90
	APOE ε4	1·20 (0·52 – 2·78)	0·67	1·34 (0·83 – 2·18)	0·23	1·69 (0·52 – 5·48)	0·38	1·34 (0·91 – 1·99)	0·14
Lobar ICH Poor Outcome*	APOE ε2	1·47 (1·10 – 2·0)	0·009	1·67 (1·15 – 2·43)	0·007	1·46 (1·02 – 2·65)	0·039	1·52 (1·25 – 1·85)	1·74 × 10−5
	APOE ε4	1·24 (0·83 – 1·85)	0·08	1·21 (0·80 – 1·85)	0·13	1·00 (0·79 – 1·26)	0·99	1·08 (0·90 – 1·30)	0·39
Deep ICH Poor Outcome*	APOE ε2	0·71 (0·41 – 1·25)	0·24	1·05 (0·68 – 1·63)	0·81	0·66 (0·26 – 1·67)	0·38	0·87 (0·63 – 1·20)	0·40
	APOE ε4	1·24 (0·59 – 2·61)	0·57	1·14 (0·76 – 1·71)	0·52	1·15 (0·27 – 4·90)	0·85	1·61 (0·82 – 1·64)	0·40

^*Defined as modified Rankin Scale 3 – 6 at 90 days post-ICH

OR = Odds Ratio, ICH = Intracerebral Hemorrhage, 95% CI = 95% Confidence Interval