Table 7.

Predictors of Outcome in Discovery Phase Deep ICH Patients

DEEP ICH POOR OUTCOME (n = 409)
Univariate			Multivariate
Variable	OR (95% CI)	p-value	Variable	OR (95% CI)	p-value
Age	1·02 (1·01 – 1·04)	0·001	Age	1·02 (1·01 – 1·04)	0·003
Sex	1·22 (0·83 – 1·78)	0·31	Sex	1·34 (0·88 – 2·01)	0·16
HTN	1·05 (0·60 – 1·83)	0·88	HTN	0·94 (0·53 – 1·67)	0·82
Warfarin Use	2·95 (1·76 – 4·94)	< 0·001	Warfarin Use	2·56 (1·50 – 4·37)	0·001
Aspirin Use	0·87 (0·59 – 1·27)	0·47	Aspirin Use	0·79 (0·52 – 1·19)	0·25
APOE ε2	0·74 (0·25 – 2·16)	0·58	APOE ε2	0·71 (0·41 – 1·25)	0·24
APOE ε4	1·34 (0·74 – 2·45)	0·34	APOE ε4	1·24 (0·59 – 2·61)	0·57

DEEP ICH MORTALITY (n = 456)
Univariate			Multivariate
Variable	OR (95% CI)	p-value	Variable	OR (95% CI)	p-value
Age	1·03 (1·01 – 1·05)	0·001	Age	1·03 (1·01 – 1·05)	0·001
Sex	1·03 (0·63 – 1·68)	0·92	Sex	1·16 (0·70 – 1·94)	0·56
HTN	1·39 (0·71 – 2·72)	0·34	HTN	1·26 (0·64 – 2·51)	0·50
Warfarin Use	2·27 (1·66 – 3·12)	< 0·001	Warfarin Use	2·55 (1·33 – 4·89)	< 0·001
Aspirin Use	1·07 (0·65 – 1·76)	0·78	Aspirin Use	0·91 (0·54 – 1·53)	0·72
APOE ε2	0·91 (0·54 – 1·51)	0·71	APOE ε2	0·68 (0·29 – 1·57)	0·36
APOE ε4	1·32 (0·66 – 2·62)	0·43	APOE ε4	1·20 (0·52 – 2·78)	0·67

Both univariate and multivariate analysis are adjusted for Principal Components 1 and 2 to eliminate possible confounding due to population stratification.

95% CI = 95% Confidence Interval, HTN = History of Hypertension, OR = Odds Ratio