Table 1.
Effects of 10 wt.% NO generating polymer (NOGen) plus exogenous SNAP infusion on hemodynamic parameters in the rabbit model of extracorporeal circuits (ECC).
| Treatment | Parameter | Baselinea | Time on ECC (hours) |
|||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||
| Control polymer ECC + SNAP infusion | MAP | 76 ± 2 (32) | 36 ± 1 (7)* | 68 ± 19 (7) | 69 ± 13 (7) | 84 ± 10 (7) |
| HR | 208 ± 7 (32) | 209 ± 7 (7) | 213 ± 13 (7) | 231 ± 6 (7) | 242 ± 4 (7)* | |
| ECC BF | 94 ± 3 (32) | 74 ± 11 (7) | 134 ± 20 (7)* | 145 ± 13 (7)* | 185 ± 9 (6)* | |
| ACT | 169 ± 4 (32) | 156 ± 4 (7) | 186 ± 10 (7) | 210 ± 9 (7)* | 220 ± 12 (7)* | |
| WBC count | 3504 ± 115 (32) | 3195 ± 425 (7) | 2844 ± 268 (7) | 2672 ± 384 (7) | 2515 ± 347 (7) | |
| 10 wt.% NOGen polymer ECC + SNAP infusion |
MAP | 76 ± 2 (32) | 34 ± 2 (6)* | 46 ± 6 (6)* | 76 ± 11 (6) | 97 ± 10 (6)* |
| HR | 208 ± 7 (32) | 209 ± 4 (6) | 201 ± 8 (6) | 222 ± 18 (6) | 223 ± 16 (6) | |
| ECC BF | 94 ± 3 (32) | 75 ± 7 (6) | 105 ± 15 (6) | 145 ± 19 (6)* | 174 ± 21 (6)* | |
| ACT | 169 ± 4 (32) | 162 ± 6 (6) | 183 ± 11 (6) | 202 ± 16 (6)* | 208 ± 22 (6)* | |
| WBC count | 3504 ± 115 (32) | 3216 ± 348 (6) | 4044 ± 895 (6) | 3423 ± 693 (6) | 3722 ± 910 (6) | |
Values are means ± SEM. () = n size.
*
p < 0.05 vs baseline; ANOVA with Student’s t multirange test.
a
Values are prior to ECC placement. MAP = mean arterial pressure (mmHg), HR = heart rate (beats/min), BF = blood flow (ml/min), ACT = activated clotting time (sec), WBC = white blood cells.