Fig. 1.

Time course for urinary protein excretion (UPE, A); urinary albumin excretion (UAE, B); and systolic blood pressure (SBP, C) in male Dahl salt-sensitive (S), chromosome 2 congenic strain [S.SHR(2)], spontaneously hypertensive (SHR) rats. A schematic of the congenic strain is shown in A, inset. The black bar designates the extent of introgressed SHR alleles on the S background. The open region on each end of the congenic segment represents the recombination interval. In A, the dashed line represents the threshold for “proteinuria” (>20 mg/24 h). Rats were maintained on low-salt diet (0.3% NaCl) for entire course of the experiment. The number of animals at each time varied from n = 50 per group (week 4) to n = 12 per group (week 20). SBP was measured by telemetry (n = 8 per group). Mean values ± SE.