Figure 4. VSV-mediated down modulation of MICA/B surface expression is not caused by apoptosis.

JE6-1 cells were incubated with 50 µM ZVAD-Fmk (ZVAD) just prior to mock infection (-) or infection with 0.01 MOI VSV10 or VSV^ΔM51. One hr post infection, the cells were treated with 20 ng/mL FR901228 (FR), where indicated. 19 hr post infection, the cells were analyzed for MICA/B surface expression by flow cytometry. The bar graphs show mean±SD from three experiments. *** p<0.0001.