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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Neurobiol Dis. 2011 Jun 6;44(1):28–37. doi: 10.1016/j.nbd.2011.05.020

Figure 6. The Expression of TIMP-1 and Activity of TIMP-1 and MMP-9 in the presence of JAK-2 and TIMP-1 inhibitors 48 hours after HI in the brain.

Figure 6

(A) Representative blot (WB) of TIMP-1 and b-actin expression and coomassie blue stain of TIMP-1 activity (dark bands) and MMP –9 activity (light bands), column 0 shows positive controls for TIMP-1 and MMP-9. (B)Densitometric quantification of western blot for TIMP-1 expression. (C) densiometric calculation of reverse zymography of TIMP-1 activity. (D) Densiometric quantification of zymography of MMP-9 activity. Data represent the mean (±SD): n = 6 in all groups represented in B, C and D. * P < 0.05 in all group compared to IgG vehicle # P < 0.05 compared to IgG + EPO group. EPO treatment increased TIMP-1 activity and expression and reduced MMP-9 activity.