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A. Site-directed fluorescence labeling of the RyR2 with MCA by using DP2246mut as the carrier. MCA fluorescence was barely detected when either an excess concentration of DP2246/2246mut (10 mmol/L) (‘cold chase’) or Ab2141 (antibody against the K201-binding domain) was added during the labeling. B, Concentration dependence of DP2246 or DP2246mut on the binding to the RyR2. Data are means±SE of 3 experiments using 3 SR preparations from 30 hearts.
