Table 3.

Change in Neuropsychiatric Test Scores at 12 Weeks by Treatment Group. Mean ± SD

Neuropsychiatric Measure	Memantine	Placebo	P Valuea
	n=30	n=17
ANAM throughput score:
Code substitution, delayed memory	−0.4 ± 14.4	2.8 ± 10.0	0.41
Code substitution, immediate memory	4.8 ± 15.2	7.6 ± 8.9	0.44
Code substitution	7.3 ± 7.2	6.2 ± 8.2	0.63
Continuous performance test	12.8 ± 12.9	2.9 ± 26.5	0.16
Matching to sample	0.6 ± 6.2	2.7 ± 4.6	0.23
Mathematical processing	3.2 ± 7.2	2.0 ± 3.9	0.46
Simultaneous spatial processing	4.1 ± 8.1	3.9 ± 3.2	0.93
Simple reaction time	14.0 ± 41.0	5.1 ± 50.4	0.51
Sternberg memory recall	7.0 ± 12.9	7.0 ± 11.4	0.99
ACR neuropsychiatric battery:
Minimental State Exam	0.2 ± 1.3	0.5 ± 1.1	0.41
Woodcock total	−0.2 ± 2.7	−0.1 ± 3.2	0.96
Trails A	−3.6 ± 10.5	−5.7 ± 14.6	0.56
Trails B	−6.9 ± 26.2	−13.8 ± 26.7	0.40
Rey total - copy	0.3 ± 3.7	1.7 ± 7.6	0.49
Rey total – immediate recall	6.7 ± 5.7	5.1 ± 6.2	0.39
Rey total – delayed recall	5.9 ± 5.6	6.4 ± 8.9	0.86
Symbol score	3.0 ± 7.4	2.1 ± 9.7	0.71
California Delay LDFR	2.6 ± 2.7	1.8 ± 3.8	0.40
California Delay LDCR	2.8 ± 2.4	1.6 ± 2.5	0.14
California Delay – Hits	0.6 ± 1.7	0.4 ± 2.4	0.71
California Delay – FP	−0.7 ± 1.8	0.2 ± 1.7	0.12
Block total	2.7 ± 7.2	6.5 ± 6.0	0.07
COWAT - F	2.0 ± 4.4	2.5 ± 4.4	0.71
COWAT - A	0.6 ± 4.3	1.6 ± 3.0	0.41
COWAT – S	3.6 ± 4.7	0.5 ± 3.8	0.03
Coding score	5.5 ± 17.5	−2.0 ± 21.1	0.20
Tap dominant	5.2 ± 9.4	3.0 ± 7.5	0.42
Tap nondominant	5.1 ± 9.7	2.2 ± 10.3	0.36
Digit forward	0.6 ± 2.1	0.6 ± 2.3	0.97
Digit backward	1.0 ± 1.7	−0.1 ± 2.3	0.07

^aFrom two-sample t-test.