Table 4.

Change in ANAM throughput scores at 12 weeks for patients that were at least 1 standard deviation below normal control data on at least one of the 9 ANAM subtests or one of the 21 ACR Neuropsychiatric battery at baseline

Neuropsychiatric Measure	Memantine	Placebo	P Valuea
	n=24	n=13
ANAM throughput score:
Code substitution, delayed memory	0.4 ± 15.0	4.7 ± 9.8	0.36
Code substitution, immediate memory	6.8 ± 15.7	7.0 ± 9.5	0.97
Code substitution	7.7 ± 7.6	7.0 ± 8.9	0.78
Continuous performance test	14.5 ± 13.5	3.2 ± 29.8	0.21
Matching to sample	1.2 ± 6.1	2.5 ± 4.9	0.51
Mathematical processing	3.6 ± 7.6	1.7 ± 3.0	0.31
Simultaneous spatial processing	5.0 ± 6.3	4.0 ± 3.6	0.55
Simple reaction time	23.2 ± 36.9	−0.3 ± 48.1	0.11
Sternberg memory recall	6.3 ± 13.5	5.9 ± 11.4	0.92
ACR neuropsychiatric battery:	n=26	n=16
Minimental State Exam	0.2 ± 1.4	0.5 ± 1.1	0.41
Woodcock total	−0.2 ± 2.9	0.0 ± 3.2	0.81
Trails A	−3.5 ± 11.3	−5.6 ± 15.0	0.62
Trails B	−6.8 ± 27.0	−15.5 ± 26.6	0.32
Rey total - copy	0.1 ± 4.0	1.7 ± 7.9	0.45
Rey total – immediate recall	6.5 ± 4.2	4.9 ± 6.3	0.41
Rey total – delayed recall	5.9 ± 5.7	6.7 ± 9.0	0.76
Symbol score	2.7 ± 7.7	1.9 ± 10.0	0.76
California Delay LDFR	2.7 ± 0.6	1.5 ± 3.8	0.24
California Delay LDCR	3.0 ± 2.5	1.6 ± 2.6	0.09
California Delay – Hits	0.7 ± 1.8	0.4 ± 2.5	0.68
California Delay – FP	−0.8 ± 2.0	0.1 ± 1.7	0.13
Block total	2.8 ± 7.7	6.8 ± 6.0	0.09
COWAT - F	2.2 ± 4.7	2.4 ± 4.6	0.85
COWAT - A	0.2 ± 4.2	1.6 ± 3.1	0.29
COWAT – S	3.1 ± 4.5	0.6 ± 3.9	0.08
Coding score	4.5 ± 18.4	−3.9 ± 20.1	0.17
Tap dominant	6.7 ± 9.4	2.7 ± 7.7	0.16
Tap nondominant	6.3 ± 10.2	2.0 ± 10.6	0.16
Digit forward	0.6 ± 2.1	0.9 ± 2.0	0.64
Digit backward	1.0 ± 1.9	−0.1 ± 2.4	0.11

^aFrom two-sample t-test.