FIGURE 2.

KLRG1–NKG2A double-positive cells constitute the majority of effector/effector-memory CD8 T cells during γHV68 persistent infection. Bar diagrams show the frequency of different NKG2A–KLRG1 subsets in the effector (CD62L^lowCD43^high), effector memory (CD62L^lowCD43^low), and central memory (CD62L^highCD43^low) CD8 T cells. Mice were infected 3 mo earlier with γHV68 (left panels), influenza virus (center panels), or kept as naive age-matched controls (right panels). Cells were gated on virus-specific (γHV68 ORF6_487–495/D^b-specific or influenza virus NP_366–374/D^b-specific) CD8 T cells as indicated. Bars represent the mean value of three experimental mice, and error bars indicate SD.