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. 2011 Jun 10;87(6):287–327. doi: 10.2183/pjab.87.287

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© 2011 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 12. — Phylogenetic tree and sequence alignment of PalB calpains. A. Phylogenetic tree of strict PalB calpains and human CAPN1/μCL. See Fig. 3A for methods. B. Sequence alignment of PalBs and human CAPN1/μCL (the start and end aa residue numbers are indicated). Triangles: active site residues. Asterisks: residues involved in Ca²⁺-binding of the protease domain of CAPN1/μCL. Arrows: domain boundaries. Deletion (−) and multiple (+) residue positions are indicated. Residue numbers of human CAPN1/μCL are given above the sequences. Residues conserved in all the sequences, all except human CAPN1/μCL, and in more than half the sequences are indicated by black reversed fonts, gray reversed fonts, and gray shadow, respectively. Sequences: 0: H. sapiens (human) CAPN1/μCL (NP_005177); 1: H. sapiens CAPN7/PalBH (NP_055111); 2: X. tropicalis (frog) (NP_998853); 3: D. rerio (zebrafish) (NP_001128580); 4: Ciona intestinalis (sea squirt) (XP_002121253); 5: Tribolium castaneum (red flour beetle) (XP_967682); 6: Apis mellifera (honey bee) (XP_001121978); 7: Acyrthosiphon pisum (pea aphid) (XP_001945029); 8: A. gambiae str. PEST (malaria mosquito) (XP_309874); 9: S. mansoni (XP_002579452); 10: C. elegans (NP_497964); 11: T. brucei TREU927 (XP_828540); 12: L. major (CAJ06528); 13: Coprinopsis cinerea okayama7#130 (common ink cap) (EAU91907); 14: E. nidulans FGSC-A4 (XP_657860); 15: C. albicans SC5314 (EAL03290); 16: S. cerevisiae (Q03792).

Figure 12. — Phylogenetic tree and sequence alignment of PalB calpains. A. Phylogenetic tree of strict PalB calpains and human CAPN1/μCL. See Fig. 3A for methods. B. Sequence alignment of PalBs and human CAPN1/μCL (the start and end aa residue numbers are indicated). Triangles: active site residues. Asterisks: residues involved in Ca²⁺-binding of the protease domain of CAPN1/μCL. Arrows: domain boundaries. Deletion (−) and multiple (+) residue positions are indicated. Residue numbers of human CAPN1/μCL are given above the sequences. Residues conserved in all the sequences, all except human CAPN1/μCL, and in more than half the sequences are indicated by black reversed fonts, gray reversed fonts, and gray shadow, respectively. Sequences: 0: H. sapiens (human) CAPN1/μCL (NP_005177); 1: H. sapiens CAPN7/PalBH (NP_055111); 2: X. tropicalis (frog) (NP_998853); 3: D. rerio (zebrafish) (NP_001128580); 4: Ciona intestinalis (sea squirt) (XP_002121253); 5: Tribolium castaneum (red flour beetle) (XP_967682); 6: Apis mellifera (honey bee) (XP_001121978); 7: Acyrthosiphon pisum (pea aphid) (XP_001945029); 8: A. gambiae str. PEST (malaria mosquito) (XP_309874); 9: S. mansoni (XP_002579452); 10: C. elegans (NP_497964); 11: T. brucei TREU927 (XP_828540); 12: L. major (CAJ06528); 13: Coprinopsis cinerea okayama7#130 (common ink cap) (EAU91907); 14: E. nidulans FGSC-A4 (XP_657860); 15: C. albicans SC5314 (EAL03290); 16: S. cerevisiae (Q03792).