Table 1.
Baseline Characteristics of 17,572 Women Initially Free of Hypertension
| Incident hypertension at 8 years (N = 4714) |
No hypertension at 8 years (N = 12858) |
P-value* | |
|---|---|---|---|
| Age, years | 53.6 (49.4,59.6) | 51.6 (48.2,56.6) | < 0.001 |
| Systolic blood pressure, mm Hg | 125 (115,135) | 115 (105,125) | < 0.001 |
| Diastolic blood pressure, mm Hg | 80 (70,80) | 70 (70,80) | < 0.001 |
| Current hormone use, % | 46.0 | 42.8 | < 0.001 |
| Diabetes, % | 2.7 | 0.9 | < 0.001 |
| Postmenopausal, % | 56.5 | 48.4 | < 0.001 |
| Black or Hispanic, % | 2.9 | 1.9 | < 0.001 |
| Current cigarette smoker, % | 11.5 | 11.4 | 0.88 |
| Alcohol use, % | < 0.001 | ||
| Rarely/never | 45.3 | 40.5 | |
| 1–3 drinks/month | 13.2 | 13.5 | |
| 1–6 drinks/week | 31.2 | 35.4 | |
| 1+ drinks/day | 10.2 | 10.6 | |
| Exercise frequency, % | < 0.001 | ||
| Rarely/never | 39.1 | 33.4 | |
| <1 time/week | 19.7 | 19.9 | |
| 1–3 times/week | 31.0 | 33.9 | |
| 4+ times/week | 10.2 | 12.8 | |
| Body mass index, kg/m2 | 25.7 (23.1,29.2) | 23.7 (21.8,26.6) | < 0.001 |
| Current cholesterol treatment, % | 2.9 | 1.9 | < 0.001 |
| Total cholesterol, mg/dL | 210 (186,238) | 204 (181,231) | < 0.001 |
| LDL Measures | |||
| LDL cholesterol, mg/dL | 122.6 (101.6,146.1) | 118.2 (98.2,140.9) | < 0.001 |
| Apolipoprotein B, mg/dL | 105.1 (86.9,124.1) | 95.3 (79.9,115.1) | < 0.001 |
| NMR LDL particle concentration, nmol/L | |||
| Total | 1350 (1091,1679) | 1191 (970,1476) | < 0.001 |
| IDL | 38 (14,74) | 26 (8,59) | < 0.001 |
| Large | 535 (388,686) | 556 (426,692) | < 0.001 |
| Small | 730 (450,1108) | 566 (340,867) | < 0.001 |
| Average NMR LDL particle size, nm | 21.3 (20.7,21.8) | 21.5 (21,22) | < 0.001 |
| HDL Measures | |||
| HDL cholesterol, mg/dL | 50.7 (42.3,61.1) | 54.2 (45.3,64.6) | < 0.001 |
| Apolipoprotein A-I, mg/dL | 149.2 (132.2,167.9) | 150.3 (134,168.5) | 0.007 |
| NMR HDL particle concentration, μmol/L | |||
| Total | 35.5 (31.5,40) | 34.6 (30.8,38.9) | < 0.001 |
| Large | 7.1 (4.6,10) | 8.2 (5.6,10.8) | < 0.001 |
| Medium | 3.1 (0.9,6.5) | 2.6 (0.7,5.8) | < 0.001 |
| Small | 24.1 (20.5,27.7) | 22.9 (19.3,26.5) | < 0.001 |
| Average NMR HDL particle size, nm | 8.9 (8.6,9.3) | 9.1 (8.8,9.4) | < 0.001 |
| VLDL Measures | |||
| Triglycerides, mg/dL | 129 (90,187) | 106 (75,153) | < 0.001 |
| NMR VLDL particle concentration, nmol/L | |||
| Total | 70.9 (51.3,93.2) | 65.3 (46.7,86.7) | < 0.001 |
| Large | 1.9 (0.5,4.2) | 1.0 (0.2,2.9) | < 0.001 |
| Medium | 22.0 (12.0,33.4) | 19.6 (10.3,30.6) | < 0.001 |
| Small | 45.9 (32.9,58.6) | 43.1 (31.1,56.4) | < 0.001 |
| Average NMR VLDL particle size, nm | 47.6 (42.9,53) | 45.5 (41.6,50.7) | < 0.001 |
Values shown are median (25 percentile, 75 percentile) unless otherwise indicated
*
Kruskal-Wallis for continuous variables, Chi-squared for categorical