Table 3. Heteroplasmic association with age and body mass index (BMI).
| Heteroplasmy | Buccal | (n = 178) | Blood | (n = 165) | Pooled | (n = 343) | |||||||||
| Prevalence: | Prevalence: | Prevalence: | |||||||||||||
| OR | p | Lower | Upper | p | OR | p | Lower | Upper | p | OR | p | Lower | Upper | p | |
| All sites | |||||||||||||||
| Age | 1.40 | 0.47 | 12% | 26% | 0.07 | 1.21 | 0.91 | 9% | 20% | 0.12 | 1.25 | 0.86 | 10% | 23% | 0.03 |
| BMI | 0.68 | 0.10 | 23% | 14% | 0.13 | 0.70 | 0.25 | 17% | 12% | 0.22 | 0.69 | 0.17 | 20% | 13% | 0.19 |
| Age (adj. BMI) | 1.28 | 0.35 | 1.31 | 1.00 | 1.00 | 0.926 | |||||||||
| BMI (adj. Age) | 0.65 | 0.10 | 0.09 | 0.66 | 0.91 | 0.21 | 0.90 | 0.181 | 0.08 | ||||||
| HVI 16093 | |||||||||||||||
| Age | 1.50 | 0.48 | 4% | 10% | 0.33 | - | - | 0% | 0% | - | - | - | 2% | 5% | - |
| BMI | 0.66 | 0.03 | 9% | 6% | 0.11 | - | - | 0% | 0% | - | - | - | 5% | 3% | - |
| Age (adj. BMI) | 1.38 | 0.80 | - | - | - | - | |||||||||
| BMI (adj. Age) | 0.59 | 0.02 | 0.26 | - | - | - | - | - | - | ||||||
| HVII 64 & 189 | |||||||||||||||
| Age | 0.67 | 0.30 | 2% | 2% | 0.87 | 0.64 | 0.25 | 2% | 2% | 0.82 | 0.66 | 0.28 | 2% | 2% | 0.99 |
| BMI | 5.35 | 0.0003 | 0% | 4% | - | 5.09 | 0.0004 | 0% | 5% | - | 5.22 | 0.0003 | 0% | 5% | - |
| Age (adj. BMI) | 0.62 | 0.235 | 0.58 | 0.20 | 0.60 | 0.22 | |||||||||
| BMI (adj. Age) | 5.42 | 0.001 | - | 5.29 | 0.001 | - | 5.35 | 0.001 | - | ||||||
| VRII 523 to 524 | |||||||||||||||
| Age | 1.08 | 0.02 | 5% | 23% | 0.01 | 1.42 | 0.19 | 6% | 21% | 0.03 | 1.52 | 0.12 | 6% | 22% | 0.02 |
| BMI | 0.59 | 0.08 | 18% | 10% | 0.03 | 0.61 | 0.14 | 17% | 10% | 0.05 | 0.61 | 0.12 | 17% | 10% | 0.04 |
| Age (adj. BMI) | 1.84 | 0.02 | 1.62 | 0.07 | 1.73 | 0.04 | |||||||||
| BMI (adj. Age) | 0.53 | 0.05 | 0.002 | 0.54 | 0.08 | 0.01 | 0.53 | 0.07 | 0.004 | ||||||
Odds ratios and corresponding p-values are reported using robust logistic regression. Heteroplasmy status is regressed upon age and BMI with univariate analyses odds ratios (OR) and model-fit likelihood ratio test (LRT) p-values presented. Adjusted odds ratios (OR) and p-values are also presented for the corresponding multiple regressions for age+BMI. Odds ratios are reported as quartiles of age and BMI (first column), with the model fit statistics (p-value) reported using the more informative continuous measures of age and BMI (second column). The p-value column reported with prevalence corresponds to the regression beta-coefficient p-values for age and BMI and multiple regression model-fit LRT p-value, respectively, with heteroplasmy regressed upon dichotomised age and BMI (upper and lower quartiles). Four individuals are observed with HVII point mutations (all 4 individuals have a BMI over 28). Twenty-two individuals are observed with VRII insertion-deletions in blood and buccal samples (between base pairs 523 to 524) and an additional 3 mutations were observed at this site in buccal samples only.