Table 3.
CRH-induced Seizures: Latency, Peptide Doses, and Age of Rat Pups
| Age (days) | n | CRH (nmol) | n | Latency (min) | Duration (hr) | Electrode Location |
|---|---|---|---|---|---|---|
| 5–6 | 10 | 0.038 | 2 | 9.0 ± 1.0a | >5;2 | A;A |
| 0.075 | 2 | 5.5 ± 0.7a | 5;>5 | A;A | ||
| 0.15 | 6 | 4.9 ± 1.5a | 2 to >5 | 2A;2DH;2VH | ||
| 8–10 | 13 | 0.15 | 11 | 5.9 ± 1.5a | all >3 | 6A;2VH;1DH;2 (A + VH) |
| 0.30 | 2 | 3;5 | >4 | A + VH;A | ||
| 11–15 | 13 | 0.08 | 1 | N/Ab | 3 | A |
| 0.15 | 10 | 3.8 ± 0.5a | 1 to >4 | 4A;2(A + DH); 1VH;3(A + VH) | ||
| 0.22 | 1 | N/Ab | >4 | A | ||
| 0.30 | 1 | <2 | 3 | A | ||
| 16–22 | 6 | 0.15 | 1 | 16 | 2 | A |
| 0.22 | 1 | 10 | <2 | A + VH | ||
| 0.3 | 3 | 4.0 ± 1.7a | 2;2;3 | DH;A;A | ||
| 0.75 | 1 | 2 | 2.7 | DH |
a
The mean plus the standard error of the mean.
b
Not available, animal restrained to control for motion artifact (see Materials and Methods)
CRH = corticotropin-releasing hormone; n = number of rats; A = amygdala; DH = dorsal hippocampus; VH = ventral hippocampus; A + VH, A + DH = simultaneous amygdala and hippocampal electrodes.