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. 2011 Aug;17(8):1489–1501. doi: 10.1261/rna.2442211

FIGURE 1.

FIGURE 1.

Conditional loss of Dicer1 in post-mitotic neurons resulted in more severe phenotypes than loss of Dgcr8. (A) Survival analysis was performed on CamK-cre93 dgcr8Δ/Δ and dicer1Δ/Δ conditional mice. P-value was determined by the log-rank test. (B) dicer1Δ/Δ animals showed increases in lateral ventricle size at rostral (bregma −0.080, P = 0.0009) but not at caudal (bregma −1.255, P = 0.94) regions. (C) The rostral (bregma −2.055, P = 0.008), but not caudal (bregma −2.48, P = 0.371), hippocampal structure was malformed and reduced in size in the dicer1Δ/Δ brains compared with dgcr8Δ/Δ. (D,E) dicer1Δ/Δ animals exhibited agenesis of the caudal CC (note the lack of callosal tracts in the dicer1Δ/Δ animal and the intact callosum in the dgcr8Δ/Δ animal). Bregma values given for corresponding coronal sections from WT animals. Error bars, SEM; all scale bars, 3 mm.