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Signaling Mechanisms that Regulate Sleep across Species
| Molecule | Drosophilaa | Mammalsa |
|---|---|---|
| Dopamine | ↑ Wake | ↑ Wake |
| GABA | ↑ Sleep | ↑ Sleep |
| Norepinephrine (octopamine) | ↑ Wake | ↑ Wake |
| Serotonin | ↑ Sleep | ↑ REM sleep NREM sleep? |
| cAMP/cAMP signaling | ↑ Wake | ↑ Wake |
| EGF signaling | ↑ Sleep | ↑ Sleep |
| Voltage-gated K+ channels (Shaker) | ↑ Sleep | ↑ Sleep |
Worms and fish are not included because many of these pathways have not yet been investigated in these systems.
