Table 4.

The Most Significant SNPs Mapped to the Leading-Edge Genes of the ROA Pathway

SNP	Gene	p Value	Role	Allele	MAFa
rs7037147	IFNA14	1.10 × 10−3	Intron	A/G	0.16
rs6883910	ATG12	2.11 × 10−3	Upstream	A/C	0.39
rs7852323	IFNA21	2.90 × 10−3	Upstream	A/G	0.17
rs1360286	IFNA5	3.16 × 10−3	Downstream	A/C	0.21
rs10964938	IFNA17	3.49 × 10−3	Upstream	A/C	0.18
rs10757219	IFNA8	4.92 × 10−3	Promoter/regulatory region	A/G	0.28
rs2015345	IFNA16	5.46 × 10−3	Downstream	A/C	0.17
rs1477479	IFNA4	6.02 × 10−3	Downstream	A/T	0.17
rs7856345	IFNA7	6.55 × 10−3	Downstream	A/T	0.18
rs17536147	ATG7	8.32 × 10−3	Intron	C/G	0.08
rs637949	IFNA13	1.21 × 10−2	Upstream	C/G	0.17
rs9955346	PIK3C3	1.57 × 10−2	Upstream	A/G	0.17
rs694433	ATG5	1.62 × 10−2	Upstream	A/G	0.21

^aMAF (minor allele frequency) in our sample.