Fig. 1.

(A) Distribution of skeletal abnormalities in patients diagnosed with HPT (n = 605). Compared with healthy controls, HPT patients have marrow fibrosis and increased osteoid perimeter, eroded perimeter, osteoclast number, and bone formation rate, but most have normal cancellous bone area. Significant correlations between skeletal abnormalities and bone marrow fibrosis are indicated by an asterisk. (B) Mast cell number in bone biopsies from a subset of 30 women with HPT are compared with 20 healthy women of similar age. Values are mean ± SE. *p < .001.