Table 4.

Mean Change from Baseline Between Groups on All Outcome Measures

Measure	Usual care mean (SD)	Naturopathic mean (SD)	Education mean (SD)	p value
Quality of Life (SF-36)
General Health	−3.1 (18.1)	7.9 (10.6)	4.8 (13.2)	0.11
MCS	−1.2 (9.0)	0.10 (6.5)	0.40 (9.7)	0.85
PCS	−0.30 (6.4)	1.5 (5.9)	1.5 (5.0)	0.64
Fatigue
MFIS (MSQLI)	−.20 (4.2)	.93 (3.0)	.29 (3.0)	0.68
MFI
Mental fatigue	3.00 (4.8)	0.53 (2.8)	−0.47 (6.2)	0.14
Depression
BDI	0.9 (5.28)	1.9 (5.89)	2.3 (5.3)	0.76
Neurologic impairment
EDSS	−0.33 (0.6)	0.20 (0.4)	−0.07 (0.8)	0.07
MSFC
Timed Walk	−0.05 (.70)	0.07 (.38)	−0.67 (1.6)	0.11
PASAT-3	0.15 (.31)	0.18 (.44)	0.32 (.38)	0.45
9-hole peg	0.13 (.52)	0.03 (.93)	−0.08 (.51)	0.71
Total score	0.09 (.37)	0.09 (.39)	−0.14 (.53)	0.24
Cognitive impairment
Stroop	−2.0 (3.8)	−2.7 (5.7)	1.0 (3.8)	0.07

Positive value reflects improvement and negative value reflects worsening.

SD, standard deviation; SF-36, 36-item short form health survey; MCS, mental component summary; PCS, physical component summary; MFIS, Modified Fatigue Impact Scale; MSQLI, Multiple Sclerosis Quality of Life Inventory; MFI, Multidimensional Fatigue Inventory; BDI, Beck Depression Inventory; EDSS, Expanded Disability Status Scale; MSFC, Multiple Sclerosis Functional Composite; PASAT-3, Paced Auditory Serial Addition Test 3.