Figure 2.

Propranolol-induced conditioned place preference (CPP) retrieval disruption is not due to nonspecific effects of propranolol or reconsolidation blockade. (a) Following conditioning, the more active enantiomer of propranolol, (−)-propranolol but not saline injections (arrows) prevented rats from expressing a CPP for the previously cocaine-paired chamber over the previously saline-paired chamber during the first and subsequent CPP trials. (b) Propranolol injection immediately before the first CPP trial did not prevent CPP expression during this trial or subsequent trials. (c) Following conditioning with propranolol or saline, rats spent an equivalent amount of time in the previously propranolol-paired and saline-paired chambers. (d) Propranolol had no effect on locomotor activity, as measured by photobeam breaks, when injected before an initial CPP trial. Prop, propranolol. ^***p<0.001, ^**p<0.01, and ^*p<0.05.