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Propranolol treatment prevents subsequent cocaine-induced reinstatement of a conditioned place preference (CPP). Saline- and propranolol-treated rats showed no CPP for the previously cocaine-paired chamber over the previously saline-paired chamber on the final extinction trials. The following day, saline- but not propranolol-treated rats expressed a cocaine-induced reinstatement of the CPP. Sal, saline; prop, propranolol. **p<0.01.
