Figure 1.

Alignment of TPR2B domains of STI1. Amino acids 353 to 477 of human STI1 (H. sapiens, GenBank NP_006810) are shown aligned to animal, fungal and plant STI1 sequences demonstrating evolutionary conservation of the TPR2B domain and residue K434 (indicated by the arrow). Alignment to the human TPR1 domain was used for homology modeling (see Figure 2). Black and gray shading represent identical and functionally-similar residues, respectively.