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Growth assay of hSTI1(K434R)/UTP21 double mutants. Combining specific sti1--interacting mutations of yeast UTP21 with the hSTI1(K434R) variant decreases the growth rate of liquid cultures at 37 °C. Although expression of the glaucoma-associated K434R variant does not affect growth in the WT or L5P UTP21 backgrounds, co-expression with the mutations UTP21(S602F) or UTP21(D621G) significantly decreased the growth rate (asterisk, t-Test of linear slopes, p<0.05, 4 experiments).
