Table 2. Aqueous humor cytokine levels in patients with intermediate uveitis and in controls.
| Inflammatory mediators | Controls (n=10) | IU patients (n=36) | Active disease (n=15) | Quiescent disease (n=21) | CME (n=7) | No CME (n=29) | Systemic therapy (n=10) | No systemic therapy (n=26) | Systemic disease (n=9) | No systemic disease (n=27) |
|---|---|---|---|---|---|---|---|---|---|---|
| Mean age (yrs) |
40 |
36 |
42 |
32 |
44 |
35 |
43 |
36 |
44 |
34 |
| Geometric mean (pg/ml)
Median (pg/ml)
Range (pg/ml)
p value | ||||||||||
| IL-1β (2.0)* |
1.4
1.1
2.2–4.5 |
2.3
2.5
2.2–6.7 |
2.1
2.1
2.2–6.7 |
2.5
2.2
2.2–4.6 |
2.5
2.5
2.2–6.7 |
2.2
2.6
2.2–5.7 |
2.3
2.5
2.2–6.7 |
2.3
2.7
2.2–5.7 |
2.5
4.0
2.2–4.5 |
2.2
3.2
2.2–6.6 |
| |
0.020 |
0.279 |
0.845 |
0.876 |
0.641 |
|||||
| IL-6 (0.5) |
3.3
4.8
0.6–31.0 |
27.5
24.5
2.0–433.1 |
66.5
57.3
5.6–433.1 |
14.6
15.4
2.1–160.6 |
86.7
64.4
5.6–433.1 |
20.8
20.7
2.0–294.0 |
40.1
34.6
5.6–358.4 |
23.8
21.8
2.1–433.1 |
32.9
42.6
2.0–295.0 |
25.9
21.5
2.3–433.1 |
|
0.001 |
0.003 |
0.026 |
0.393 |
0.693 |
||||||
| IL-8 (0.4) |
2.6
3.8
0.4–7.9 |
14.2
15.6
1.0–84.0 |
34.0
25.8
9.2–183.9 |
7.6
5.9
1.0–57.1 |
40.4
25.8
15.5–83.9 |
11.0
9.2
1.0–106.7 |
26.2
24.4
3.8–183.9 |
11.2
10.3
1.0–106.7 |
17.6
26.8
2.9–68.4 |
13.2
13.6
1.0–183.9 |
| |
<0.0001 |
<0.0001 |
0.012 |
0.074 |
0.565 |
|||||
| IL-10 (1.5) |
1.1
2.6
1.7–2.2 |
2.0
2.8
1.7–14.7 |
2.5
3.0
1.7–14.7 |
1.7
2.5
1.7–5.5 |
2.5
2.8
1.7–4.3 |
1.9
2.0
1.7–14.7 |
2.1
2.6
1.7–3.6 |
1.9
2.0
1.7–14.7 |
2.1
2.5
1.7–5.5 |
2.0
2.1
1.7–14.7 |
| |
0.005 |
0.062 |
0.054 |
0.256 |
0.641 |
|||||
| TNF-α (2.0) |
2.0
2.8
2.4–3.3 |
2.4
2.6
2.4–5.4 |
2.7
2.8
2.4–5.2 |
2.2
2.8
2.4–5.4 |
3.1
3.3
2.4–5.2 |
2.2
2.7
2.4–5.4 |
3.2
3.0
2.4–5.2 |
2.9
2.6
2.4–5.3 |
2.3
2.7
2.4–5.2 |
2.3
3.0
2.4–5.4 |
| |
0.323 |
0.462 |
0.094 |
0.135 |
0.247 |
|||||
| IL-12p70 (1.5) |
1.0
0.9
1.7–2.0 |
2.1
2.7
1.7–5.9 |
2.1
2.5
1.7–5.9 |
2.2
3.0
1.7–4.8 |
2.8
2.5
1.7–5.9 |
2.0
2.8
1.7–4.8 |
2.4
3.0
1.7–5.9 |
2.1
2.5
1.7–4.8 |
2.5
3.0
1.7–4.8 |
2.0
2.5
1.7–5.9 |
| |
0.003 |
0.505 |
0.480 |
0.520 |
0.565 |
|||||
| CCL5/RANTES (0.02) |
1.8
1.5
1.1–3.9 |
3.6
2.3
0.0–76.5 |
6.3
3.7
0.5–59.4 |
2.1
2.0
0.0–76.5 |
8.4
8.5
2.0–59.4 |
2.9
2.1
0.0–76.5 |
4.5
5.7
0.0–43.0 |
3.3
2.1
0.5–76.5 |
8.9
8.5
0.5–76.5 |
2.7
2.3
0.0–59.4 |
| |
0.091 |
0.033 |
0.078 |
0.355 |
0.192 |
|||||
| CCL3/MIP-1α (4.0) |
3.2
3.1
4.1–9.1 |
4.0
4.9
4.1–15.2 |
4.5
5.3
4.1–8.0 |
3.7
4.8
4.1–15.3 |
3.9
4.2
4.1–8.0 |
4.1
5.0
4.1–15.3 |
4.2
4.7
4.1–8.0 |
4.0
5.2
4.1–15.3 |
5.0
5.0
4.1–15.3 |
3.8
4.8
4.1–8.0 |
| |
0.812 |
0.202 |
0.907 |
0.931 |
0.368 |
|||||
| CCL4/MIP-1β (3.0) |
27.9
24.3
19.0–43.8 |
34.6
32.3
16.4–190.9 |
35.5
34.4
16.4–85.0 |
34.0
30.2
16.9–190.4 |
33.8
34.4
16.4–85.0 |
34.8
32.0
16.9–190.4 |
34.5
32.3
16.4–190.4 |
35.1
31.8
18.4–85.0 |
39.7
32.7
16.9–190.4 |
33.1
30.5
16.4–85.0 |
| |
0.350 |
0.657 |
0.876 |
0.821 |
0.720 |
|||||
| CCL2/MCP1 (3.0) |
235.9
232.4
140.3–415.5 |
595.7
417.5
143.4–4230.1 |
888.6
846.7
214.6–3270.0 |
447.7
316.9
143.1–4230.1 |
857.4
846.7
222.7–2536.0 |
545.6
361.0
143.1–4230.1 |
767.9
781.0
214.6–3270.0 |
540.3
356.3
143.1–4230.1 |
901.0
959.9
143.1–4230.1 |
519.0
363.9
200.1–3270.0 |
| 0.003 | 0.033 | 0.236 | 0.320 | 0.157 | ||||||
*: lower detection limit for each cytokine (pg/ml). IU: intermediate uveitis; CME: cystoid macular edema.