Figure 4. Treatment with ciprofloxacin for 7 days followed by inoculation with E. coli Nissle.
Sets of three mice were used in each experiment. CFU counts of the inoculated strains from faecal samples of mice. CFU of the inoculation suspension is shown at day 0 (∼109 CFU/mouse). Black arrow indicates the initiation of ciprofloxacin treatment from day 6–13 (0.2 mg/mouse) every 6 h. Blue arrow indicates initiation of inoculation with E. coli Nissle strain at high levels (∼109 CFU/mouse) every day throughout the experiment. IBD associated E. coli strain 2 was apparently eradicated by 7 days of treatment with ciprofloxacin; however, strain 2 once again reappeared under treatment with E. coli Nissle. Each graph represents the CFU counts of three mice and bars represent SEM. Detection Limit (DL) at 20 CFU/g faeces (dotted line).