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. 2011 Aug 10;6(8):e23092. doi: 10.1371/journal.pone.0023092

Figure 1. Infectivity of SIVsmE660 challenge stock in Mauritian cynomolgus macaques.

Figure 1

Levels of plasma SIV RNA measured by qRT-PCR with R/U5 primers following multiple SIVsmE660 challenges in an in vivo titration of unvaccinated Mauritian cynomolgus macaques. Red arrow shows point of SIVsmE660 inoculation (day 0). Plasma SIV RNA levels are shown for individual macaques (B1–B8) and (B95–B100) in two independent titration series (panels A and B respectively) comparing acute, peak and steady-state chronic phases of virus replication post-SIVsmE660 challenge. Outcome of administering high dose (low dilution) viral inocula for pairs of macaques receiving a 1/10 (Group 1 ; B1, B2), 1/100 (Group 2; B3, B4); 1/1000, (Group 3, B5, B6), and 1/10,000 (Group 4, B7, B8) dilution of virus are shown in panel A. Plasma viraemia for the second dilution series at 1/10,000 (Group 5; B95, B96), 1/100,000 (Group 6; B97, B98) and 1/1,000,000 (Group 7, B99, B100) dilutions are shown in panel B. No evidence of plasma virus was detected in B97, B99 and B100 at any time point.