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. 2011 Aug 10;6(8):e23092. doi: 10.1371/journal.pone.0023092

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Berry et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Kinetics of virus replication post-SIVmacC8 vaccination measured by SIVmac251/C8-specific quantitative RT-PCR in 20 weeks (Group A) and 3 weeks (Group B) vaccinates. Blue arrow shows point of SIVmacC8 inoculation, red arrow point of SIVsmE660 challenge. Differences in vaccine kinetics between vaccinates in Panel A, Group A (B202–B205), after the peak of virus replication was seen, prior to SIVsmE660 challenge. Panel B, shows a single time-point 21 days post SIVmacC8 inoculation, ie day of SIVsmE660 challenge. In both Groups A and B, recrudescence of the vaccine virus SIVmacC8 upon SIVsmE660 challenge is shown.