Figure 5.

Binding of PIAS3 to the promoter region of target genes: Using a promoter tiling array we looked for areas of PIAS3 binding to various genes that are targets of the newly described binding partners of PIAS3. Blue bars indicate areas of PIAS3 binding along the genes of interest (green lines). (A) cMyc promoter (target of PIAS3/STAT3 comples, used as positive control); (B) TopBP1 promoter (target of EGR1); (C) TBP promoter (target of ETS); (D) CYP2C8 promoter (target of NR1I2); and (E) PPOX promoter (target of GATA1).