Figure 8.

Network contains downregulated genes (green) and upregulated genes (red) identified around EGR1 gene. Top functions of the genes were involved in cell survival, proliferation, inflammatory responses and tumor suppression. Genes were identified as differentially expressed in our experiment and were integrated into the computationally generated networks on the basis of the evidence stored in the IPA knowledge memory of available scientific data indicating a relevance to this network. The node shapes denote enzymes, phosphatases, kinases, peptidases, G-protein coupled receptors, transmembrane receptors, cytokines, growth factors, ion channels, transporters, translation factors, nuclear receptors, transcription factors and others.