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. 2011 Jul 15;12(2):152–157. doi: 10.4161/cbt.12.2.15734

Figure 1.

Figure 1

Cells from SAC-transgenic mice secrete SAC-activity. (A) SAC-MEFs induce apoptosis of co-cultured tumor cells. MEFs from SAC-or GFP-transgenic mice were cocultured with the indicated cell lines for 24 h and apoptosis was examined by ICC for active caspase 3. (B) SAC-protein in the CM from MEFs of SAC-transgenic mice induces apoptosis of cancer cells in culture. CM from the MEFs of SAC- or GFP-transgenic mice was incubated with various cell lines for 24 h and apoptosis was examined by ICC for active caspase 3. (C) SAC-protein in the serum of SAC-transgenic mice induces apoptosis of cancer cells in culture. Aliquots of serum samples from the SAC- or GFP-transgenic mice was incubated with various cell lines for 24 h and apoptosis was examined by ICC for active caspase 3.