Figure 6.

Recombinant Par-4 or SAC protein inhibits the growth of metastatic tumors. LLC1 cells (1.5 × 10⁵ cells) were injected into the tail vein of B6C3H mice. After 5 h, the mice were injected via the tail vein with the indicated recombinant protein (500 µg per mouse). Four weeks later, the mice were humanely killed and the lungs were photographed (right). The lung nodules were scored and the data are expressed as tumor index (left). Mean values (±standard deviation bars) are shown. Asterisk (*) indicates the difference between TRX and TRX-Par-4 treatment is statistically significant (p = 0.0069) and (**) indicates the difference between TRX and TRX-SAC is statistically significant (p = 0.0003) by Student's t-test.