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. Author manuscript; available in PMC: 2011 Aug 11.
Published in final edited form as: Nat Struct Mol Biol. 2008 Nov 16;15(12):1263–1271. doi: 10.1038/nsmb.1514

Figure 7.

Figure 7

Transcription kinetics of endogenous yeast genes. (a) The combinations of transcription rate constants that result in statistically significant models for MDN1 are shown as circles designating a particular value of a, b and c (min−1), with τ implicit. 1/fraction = (a + b)/a. Models that fit the mRNA abundance only are shown in open green circles; models that fit both the mRNA abundance and the nascent-mRNA loading are shown in closed black circles (χ2 significance level = 0.10). Simulated Monte Carlo time traces for MDN1 transcription using the parameters corresponding to the parameters used for the regions in red and blue circles are shown on the right. The black line shows the occupancy level of the gene; the red line shows the activation state of the gene (high = active, low = inactive); the vertical green lines mark single initiation events. (b,c) Parameters describing the expression kinetics of POL1 and PDR5.