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. 2011 Aug 10;6(8):e23256. doi: 10.1371/journal.pone.0023256

Figure 4. BTZO-15 induces HO-1 and GST Ya protein expression in the rectum of rats with DSS-induced colitis.

Figure 4

Colitis was induced in rats by daily treatment with 2.3% DSS solution in drinking water for 7 days. During this period, the rats were orally administered BTZO-15 (3 mg/kg, b.i.d.) or vehicle (0.5% MC). Rectal HO-1 (A) and GST-Ya (B) protein expression was assessed after excision and homogenization in PBS supplemented with 0.1% NP-40. The amount of GST Ya and HO-1 protein was quantified using ELISA. Results shown are the mean ± S.E.M, n = 8. * P≤0.05: compared the DSS (−) vehicle control group with DSS (+) vehicle control group using Aspin-Welch test. # P≤0.05: compared the DSS (+) vehicle control group with DSS (+) + BTZO-15 treated groups with Student's t test.