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. 2011 Aug 10;6(8):e23256. doi: 10.1371/journal.pone.0023256

Figure 5. BTZO-15 ameliorates TNBS-induced colitis in rats.

Figure 5

Colitis was induced in male F344/Du rats by topical intracolonic application of a TNBS solution. BTZO-15 was orally administered to rats at the indicated doses of 10 mg/kg (b.i.d.) for 4 days from experimental day 1 to 4 (A). The efficacy of BTZO-15 was evaluated using the size of the rectal ulcer (B), MPO activity (C), and TNF-α level in rectum. Results shown are the mean ± S.E.M. TNBS-treated group, n = 6; TNBS untreated group, n = 2. ** P≤0.01: compared the DSS (−) vehicle control group with DSS (+) vehicle control group by Aspin-Welch test, and # P≤0.05 compared the DSS (+) vehicle control group with DSS (+) + BTZO-15 treated groups with Student's t test (B). * P≤0.05: compared the DSS (−) vehicle control group with DSS (+) vehicle control group using Aspin-Welch test, and # P≤0.05 compared the DSS (+) vehicle control group with DSS (+) + BTZO-15 treated groups by Aspin-Welch test (C and D).