Figure 7.

Autophagy/mitophagy in stromal cells from the dermis of wild-type and Cav-1^-/- mice. Paraffin-embedded sections from the skin were stained with a LC3 antibody, to evaluate the degree of autophagy in stromal cells in the dermis of wild-type (A) and Cav-1^-/- mice (B). Note that an increased number of stromal cells are positive for LC3 in the dermis of Cav-1^-/- mice, in comparison to wild-type mice. The skin sections of these two groups were also stained with BNIP3L, a mitophagy marker. A marked increased in the number of dermal stromal cells that are positive for BNIP3L was observed in Cav-1^-/- mice (D), in comparison with wild-type mice (C).