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. 2011 Jun 30;15(3):123–128. doi: 10.4196/kjpp.2011.15.3.123

Fig. 4.

Fig. 4

Arginase inhibition results in increased NO production and decreased superoxide generation in isolated mice aorta. Incubation of mice aortic rings with CLE (20 µg/ml, 16 hours) resulted in a significant decrease in arginase activity (A, * vs. untreated, p<0.01, n=4). (B) Pretreated aorta were loaded with DAF (5 µM) followed by measurement of fluorescence (endothelial side up). The graph shows representative traces of DAF fluorescence in CLE- and CLE plus L-NAME (10 µM)-treated aorta. (C) The slope of DAF fluorescence was monitored and then determined (* vs. untreated, p<0.01; # vs. CLE, p<0.01; n=4 mice). (D) ROS production in the aortic endothelium was traced at different time points after preloading with DHE (5 µM). (E) The slope of DHE fluorescence was determined based on cumulative data (* vs. untreated, p<0.01; # vs. CLE, p<0.01; n=4 mice).

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